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The weather turned in 1959, however, and during the next two years China experienced a severe combination of floods and drought.
The Federal Reserve chairman, Ben S. Bernanke, again strongly urged Congress on Tuesday to ward off the sudden and severe combination of tax increases and spending cuts coming at the end of the year.
The coupled plates are commonly seen in flight vehicle structures, which are always subjected to a severe combination of thermal, aerodynamic and mechanical loads during the cruise.
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The function of PhAGL6 in Petunia was indeed only revealed in double mutant combinations with PhSEP3 [ 17] and similarly the moderate mfo1 phenotype in rice became severe in combination with a mutation in the SEP-like gene LHS1 [ 16].
The severity of the AE is graded according to the NCI/CTCAE 4.0 grading criteria into mild, moderate, or severe, in combination with the degree of limitation in activities of daily living.
Combination therapy proved both efficacious and well tolerated; syncope was notably less frequent and severe in the combination treatment arm than that reported in the AIR trial, possibly because of background bosentan therapy.
"The current crisis in Europe is the result of a severe and intertwined combination of banking sector fragilities and sovereign debt crisis," Mr. Rehn said in a statement.
Patients usually present with severe headache in combination with photophobia, seizures, or other focal neurologic findings [4].
In fact, for severe manic states, combination therapy is recommended as a first-line treatment (Yatham et al. 2009; Ketter 2008).
For example, event based SIPS can respond immediately after a severe contingency, or combination of contingencies, rather than waiting for the inevitable degradation of the system state.
These studies illustrate that in a subgroup of patients (i.e., patients with high bone turnover and/or severe osteoporosis), specific combination treatments such as HRT with bisphosphonates, calcitonin, or androgens (and perhaps also with PTH, fluoride, nitric oxide donors) provide additional beneficial effects over a single-drug therapy.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com