Sentence examples for severe cohesion from inspiring English sources

However, ctf4 and chl1 deletions cause a less severe cohesion defect compared to eco1 inactivation.

eco1∆ wpl1∆ cells exhibited a severe cohesion defect (more than 60% of cells had two GFP spots), which was reduced by half by the smc1-D1164E suppressor.

As expected, SMC1-AID and SMC3-AID cells showed severe cohesion defects that could be rescued by SMC1 and SMC3, respectively.

DOI: http://dx.doi.org/10.7554/eLife.11315.008 To begin to test this hypothesis, we first asked whether smc1-D1164E or smc1-Y1128C were also cohesion activator mutations, i.e. suppressed the severe cohesion defect of eco1∆ wpl1∆ cells.

We also show that cohesion activator mutations in key residues of the Smc3 ATPase active site, smc1-D1164E and smc1-Y1128C, suppress the severe cohesion defect of eco1∆ wpl1∆ cells, similar to the previously described smc3-D1189H allele (Guacci et al., 2015).

We define the 3 aberrant PCG categories as; 1) PCGI (mild), 1 4 chromosomes exhibit PCGs but are still in close proximity, 2) PCGII (moderate), ≥5 chromosomes exhibit PCG but are still in close proximity, and 3) PCGIII (severe), all cohesion appears to be lost as chromatids appear randomly distributed throughout the spread).

The report points to a "severe lack of cohesion right across the system between primary and secondary schools".

These underlying Arab-made structural problems include corrupt and incompetent governance, weak citizenship, brittle statehood, and a severe lack of cohesion among different ethnic and sectarian groups within countries.

Yet experiences from a UK Department for International Development funded project in Nigeria suggest that greater critical attention must be given to the impacts and effects of HIV/AIDS on communities, and the ways in which conflict can develop, emerge and be sustained, resulting in severe breakdown of social cohesion and reduction or cessation of HIV/AIDS activities.

Moreover, the smc1-D1164A or smc3-D1161A cells were both severely compromised for cohesion, although the cohesion defect in smc3-D1161A was more severe.

In addition, the enterprises in this industry are dispersed and have little industrial cohesion, and face severe and vicious competition.