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Although many patients with somatic NLRP3 mutations may have milder clinical phenotypes or later-onset disease (2, 3), the clinical severity of our patient's phenotype is consistent with the known severe clinical impact of the p.F566L mutation.
In situations with a direct conflict in the information between the different databases, where possible, the information with the most severe clinical impact is displayed.
Scores of 0 10, 11 20, 21 30, 31 40 represent mild, moderate, severe or very severe clinical impact, respectively [ 8].
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Each rater graded the error or optimisation case for severity of clinical impact using a 5-point categorical scale (no, minor, moderate, severe and life threatening/saving clinical impact).
The other recorded parameters have varying clinical specificity and severity, from mild to severe, but typically have little clinical impact, and may be very transient.
Abdominal compartment syndrome has been described in patients with severe acute pancreatitis, but its clinical impact remains unclear.
The clinical impact of severe hypertension is not insignificant, and is associated with the risk of cardiovascular complications and arterial thromboembolic events (Ranpura et al, 2010, 2011).
RD is highly prevalent in patients admitted due to severe heart failure, with a clinical impact on blood transfusion, length of stay, and determining a trend to higher mortality.
Portal hypertension leads to the formation of portosystemic collateral veins, of which Esophageal Varices (EV) have the greatest clinical impact and the most severe complications.
The clinical impact of AS is severe and its progression leads to disability With appropriate treatment, patients with AS can live relatively normal, independent lives The clinical impact of AS is severe and its progression leads to disability With appropriate treatment, patients with AS can live relatively normal, independent lives.
The clinical impact of invasive aspergillosis on severe influenza may be more important than previous thought.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com