Because of its hyper-acute and severe characteristics, it is described as thunderclap [2].
Despite the large similarities with CMDs, GFAP-Cre/DG-null mice did not recapitulate the most severe characteristics observed in the brain of patients affected by WWS.
Differences in defense mechanisms, and the more severe characteristics of LRTIs than URTIs, may account for the increased risk of LRTIs [ 43, 44].
In addition, compromised dopaminergic transmission but also more severe characteristics such as Purkinje cell degeneration and demyelination of peripheral nerves leading to ataxia have been reported in Prnp−/− animals.
Interestingly, KO animals for the gene encoding PrPC exhibit phenotypes with impaired long-term potentiation (14– 16), abnormal circadian rhythm (17) or effects on glutamatergic transmission (18, 19) but also more severe characteristics such as Purkinje cell degeneration and demyelination of peripheral nerves leading to ataxia (11, 20).
The reduction in β-cell surface observed in Sei1-null mice was of intermediate magnitude when compared with the severe defect characteristic of Cdk4-null mice (Fig. 8C).
They identified homozygous missense mutation in the RAD51C gene in a consanguineous family with multiple severe abnormalities characteristic of FA.
In all cells, TAA caused severe and characteristic damage to the majority of mitochondria, whether or not there were nuclear aberrations.
From a medical standpoint, R. slovaca infection seems to be the most important SFG rickettsiosis in central Europe because of the severe and characteristic symptoms that occur after being bitten by these ectoparasites.
For the synthetic data set, we find that the ranks of the pseudo genes g46 (with slight outlier characteristics) and g53 (with severe outlier characteristics) discovered by MFSelector are not different (similar DEtotal value) but their ranks are significantly different for the Cuzick-test and the modified M statistic test.
Compared to subjects with higher platelet density, they had more severe inflammatory characteristics.
