The expression levels of these target genes were measured in RNA pools prepared from TZ tissues designated as having mild, moderate, and severe BPH changes, as well as moderately and poorly differentiated prostate cancer.
Some differences in the chromosomal rearrangements between the subtypes, such as 17q and 11q deletions, as well as mutations in the ATM, are thought to be associated with the unmutated subtype, while less severe changes, such as 13q deletions, are associated with the mutated IGVH subtype.
Also we excluded any vertebrae showing moderate to severe degenerative changes, as severe changes may make border distortion and reading errors.
Temperatures are predicted to rise by up to 4°C by 2100, as are severe changes in precipitation patterns [ 1].
She was forced to make severe changes to her lifestyle as described by the following statement: I'm not used to counting every penny.
We reported earlier that such ovarian cystadenoma cell cultures undergo severe changes in DNA ploidy as they approach crisis and that such changes are an important determinant of crisis independent of telomere attrition.
As the severe changes of the intestinal epithelium caused by loss of E-cadherin were not compatible with life, precluding a more detailed study of E-cadherin's role in differentiation and localization of cells, a milder recombination protocol allowing mice to survive for a longer period was developed.
The xenogeneic grafts still showed cystic lesions, no fusion between host and graft cartilage and severe changes of cartilage degradation such as decreased metachromasia and hypocellularity were found in the host cartilage.
Although speculative, our data suggest an involvement of central mechanisms and seem to precede severe changes of the shoulder joint, such as RCT arthropathy.
The behavioral variant of frontotemporal dementia (bvFTD) is characterized by severe changes in behavior and personality such as disinhibition, apathy, loss of empathy, or stereotypic behavior, leading to a loss of social competence [ 73, 109, 127, 151].
