Sentence examples for severe change of from inspiring English sources

Any severe change of this mechanism leads to a growth instability, which induces an alteration of the thin film morphology.

Although speculative, our data suggest an involvement of central mechanisms and seem to precede severe changes of the shoulder joint, such as RCT arthropathy.

The density of the lesions was approximated to be the same as for the healthy lung tissue since we aimed to model less severe changes of COPD.

It has to be remembered that only severe changes of the condylar head and glenoid fossa can be evaluated on a PTG (Fig. 8) [17].

Instead, we detected severe changes of the cardiac tissue and could demonstrate apoptosis of cultured cardiomyocytes caused by oleic acid.

Thus, the sole effects of mutated GNEM712T on the mRNA levels of ST3Gal5 (i.e. a decrease of 35.6% ±10% may not translate into such severe changes of GM3 in muscles (roughly 82% of diminution).

As the severe changes of the intestinal epithelium caused by loss of E-cadherin were not compatible with life, precluding a more detailed study of E-cadherin's role in differentiation and localization of cells, a milder recombination protocol allowing mice to survive for a longer period was developed.

Besides severe changes of systemic and renal haemodynamics, the infusion of contrast media has negative effects on renal tubular cells.

Lipodystrophies cause severe changes of whole-body energy metabolism and are commonly associated with insulin resistance, hepatic steatosis, hypertension and other metabolic dysfunctions.

ILD-PH was defined as pre-CPH with moderate or severe changes of ILD on HRCT with FVC ≤70% predicted [ 12, 22].

The disassembly of ATP synthase dimer rows is accompanied by severe changes of cristae morphology with disappearance of the typical lamellar cristae in yeast mutants lacking dimer-specific subunits (35, 36).