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Another mechanism is an anti-inflammatory effect that the N-terminal lectin-like domain of rhTM exhibits, which is to sequester and cleave HMGB1, which is released from necrotic cells and modulates several signals that induce a proinflammatory response leading to severe cell damage [ 13].
The thermo-sonication combination synergistically reduced the number of sublethal cells and also resulted in severe cell damage.
Thus, functional alterations in mitochondria therefore have enormous potential for causing severe cell damage and play important roles in the pathophysiological process of cerebral ischemia.
It is well known that without proper surface modification the Cd-related quantum dots will cause severe cell damage after 24 h.
The plasma level of oxLDL was shown to be a predictor of mortality in patients with chronic congestive heart failure [157] and induced severe cell damage in ventricular myocytes [158].
In addition, high plasma LDH activity indicated severe cell damage.
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This may either be explained by functional redundancy or the need to repress several cell wall functions and/or components in order to cause severe cell wall damage.
We found that heat shock treatments at or above 66 °C caused severe cell structural damage, including a loss of membrane integrity and cell shrinkage (fig. 1 B).
It is considered as crucial structural cell wall component since in baker's yeast the lack of CCW12 results in severe cell wall damage and reduced mating efficiency.
Acute liver failure (ALF) is a type of severe liver cell damage caused by viruses, drugs, toxins, or alcohol.
In addition, severe neuronal cell damage was found, while BrdU-positive cells and the expression of BDNF in the dentate gyrus of the hippocampus were decreased after 5 weeks of CMS procedure.
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