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Moreover, 1 1 combination treatment with both PIPs demonstrated prominent antiproliferative synergy (CI value [ED50] = 0.256) to HeLa cells as a result of inducing apoptosis-mediated severe catastrophe of cell-cycle progression.
At the state level, Florida taxpayers spend a quarter of a billion dollars annually just for the option to borrow money if a severe catastrophe strikes.
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According to the Institute for Policy Integrity's analysis, "Flooding the Market", the flood insurance program's subsidies help wealthy Americans with large beachfront properties or vacation homes in a typical year, and low-income individuals only during severe catastrophes.
Analysts say the gains reflect the market's sense that a severe nuclear catastrophe that seemed possible at the end of the day on Wednesday appeared far less likely Thursday morning.
Combination of glacial hazards such as hazards from glacial clad volcanoes, glacier related flood, paraglacial mass movement lead to the most severe glacier catastrophe.
This number would maintain good health over five generations despite (a) increased inbreeding resulting from a relatively small human population, (b) depressed genetic diversity due to the founder effect, (c) demographic change through time and (d) expectation of at least one severe population catastrophe over the 5-generation voyage.
"The Specter defection is too severe a catastrophe to qualify as a "wake-up call".
We find DNA damage and stress response activation upon inhibiting Hdacs1,2, which corroborates previous findings that loss of Hdacs1,2 causes severe mitotic catastrophe [ 8].
And an environmental catastrophe severe enough to kill all the bees would likely take out many of those other pollinators as well, scientists say, which would be a planetary catastrophe for us, too.
This is not the first time a highly innovative approach to a severe disease has caused catastrophe.
But it typically takes years to recover from a catastrophe as severe as Haiyan.
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