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In this animal study, high-altitude ICH animals manifested lower PbtO2, higher levels of LPR and glutamate, and more severe brain lesion and neurological outcomes than low-altitude ICH.
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Of the 32 patients theoretically eligible as organ donors before effective WoWt measures in our study, 22 presented severe brain lesions and were de facto, unable to express their wishes.
In a recent case, Zika virus was found in the brain, bone marrow and spinal fluid of a stillborn baby who had severe brain lesions, he said.
Severe brain lesions (high grades IVH and cystic periventric'ular leukomalacia) and neonatal mortality were found not different between the two groups.
Severe brain lesions (high grades intraventricular haemorrhage and cystic periventricular leukomalacia) and neonatal mortality were not found different between the two groups.
It is also agreed that BPD has an unfavourable effect on the cognitive outcome of children born very pre-term that seems to persist into school age even in the absence of severe brain lesions [ 26].
It is possible that those patients would have shown more-severe brain lesions, as suggested by postmortem neuropathologic studies [ 22].
In patient 1 by far the smallest ratio of stained/unstained mitochondria in the liver coexisted with the severest brain lesions on MRI; on the other hand liver transaminases were unremarkable.
To study whether transient hyperglycaemia adversely affects cerebral energy metabolism in patients with severe traumatic brain lesions.
However, Diaz-Parejo and coworkers [ 19] suggested that transient moderate hyperglycaemia had no adverse effect on outcome in patients with severe traumatic brain lesions and stroke.
Similar lesions, however, can also be seen in severe inflammatory brain lesions, for example in a subset of patients with acute multiple sclerosis or with virus infections of the white matter like herpes simplex virus encephalitis, cytomegalovirus encephalitis, or progressive multifocal leukoencephalopathy [ 1].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com