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Recently, a detailed microsatellite analysis has suggested non-independent domestication of indica and japonica, although this research found a more severe bottleneck to the establishment of japonica than to that of indica [11].
For those required to make specific requests for computing time at computing centers or on the Cloud, this can be a severe bottleneck to initiating their research.
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A low number of haplotypes for most of the genes suggests a severe bottleneck at some time prior to or during the development of the domesticated species.
These results are compatible with a severe bottleneck at each new infection.
Fixed replacement mutations among the Atlantic and Non-Atlantic groups of S. fimbriatum indicate that both lineages went through a severe bottleneck, which led to the fixation of slightly deleterious mutations.
In particular, species which produce small numbers of offspring tend to undergo a more severe bottleneck event, in order to guarantee the survival and viability of the (few) members of the future generation.
We note, however, that K is inversely related to the severity of the bottleneck and that small values correspond to severe bottlenecks and large values to less severe bottlenecks.
This high rate of shared mutations between the two PbMut clones was probably due to a severe bottleneck effect during each mouse passage, where 100 1,000 infected erythrocytes were inoculated intraperitoneally, corresponding to intravenous injection of 10 100 infected erythrocytes.
So when the number of alleles is below equilibrium, as after a severe bottleneck, selection intensity is predicted to be higher than it is after equilibrium in allele number is achieved [ 2].
Most breeds would not have been subject to as severe bottleneck events during their recent genetic history as Irish Wolfhounds have [ 11], and even in breeds that have gone through comparable bottleneck events, the elimination of inbreeding depression through purging following such events is one possible consequence, but by no means an obligatory occurrence [ 8, 9].
The Swedish population seems to have experienced a more severe bottleneck than the Norwegian as only one haplotype, closely related to NO1, is found among indigenous animals [ 11, 14].
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