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Over all, 35 additional patients taking prasugrel suffered from severe bleeding compared with those taking Plavix.
The experimental treatment also increased the risk of severe bleeding compared with Plavix, and quadrupled the risk of fatal bleeding, though the risk was still relatively small.
Amongst the three criteria of severe dengue in WHO 2009 classification, a significantly lower proportion of metformin users experienced severe bleeding compared with non-users (20.7% v. 9.2%, P = 0.02).
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In an attempt to identify some determinants of ICU-acquired severe bleeding, we compared the main characteristics of patients who did and did not develop severe bleeding during the ICU stay (Table 4).
In an attempt to identify some determinants of ICU-acquired severe bleeding, we compared the main characteristics of patients who did and did not develop severe bleeding during the ICU stay (Table 4).
Only 2percentt of soldiers with severe bleeding in those countries died compared with 7percentt in Vietnam in part because tourniquets were in widespread use and the injured were quickly transported to doctors.
Even though, 5% DENV patients had severe bleeding and severe organ involvement compared with none among the DENV-HIV patients, statistical significance could not be assessed (Supplemental Table 2).
For policy planners, the nation-wide cost burden of severe bleeding in trauma can be compared with that of other conditions, and potential future costs, such as those resulting from an aging population, can be modelled.
Other nonvitamin K oral antagonist oral anticoagulants (NOAC, dabigatran, rivaroxaban, and apixaban) have proven to be superior or at least equivalent for stroke prevention and occurrence of severe bleeding complications in patients with NVAF compared to dose-adjusted warfarin.
Moderate or severe bleeding was 1.9-fold higher in women compared to men (13.3% vs 7.1%, p <0.0001).
Our study suggested the potential protective effect of metformin on dengue severity particularly on severe bleeding.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com