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The resulting structure may exhibit severe backbone clashes at the dimeric interface depending on the backbone dissimilarity between the target and template proteins.
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The unique nature of the proline side-chain imposes severe constraints on the polypeptide backbone, and thus it seems likely that it plays a special structural or functional role in the architecture of proteins.
Severe deformation with broken DNA backbones has been observed in protein-DNA complex structures that are not related to gene regulation.
In spite of this severe information reduction, it gives a description of the backbone of the system interactions controlling the correlation properties of the system.
The most interesting/important of these is the additional contact made with the backbone of M78 (from the same subunit) that leads to a severe steric clash with the side chain of V268.
Further education colleges are the backbone of training for many 16 to 18-year-olds and have faced severe cuts in recent years.
Hence, defining a finite set of possible backbone conformations by sampling the single θ1,3 parameter for each flexible residue, should not be prone to severe undersampling.
A backbone".
They are the backbone.
He wants backbone.
He has no backbone".
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