"I always like the severe in architecture, music, men and women, books, &c.
Visitors to Charleston often remark on the Citadel, and how its severe, fortresslike architecture seems to clash with the otherwise genteel, ornate atmosphere of South Carolina.
Actually, these instructions were aesthetic; Higginson also wrote to McKim: "I always like the severe in architecture, music, men and women, books".
In these works, such as The Soothsayer's Recompense (1913) and The Mystery and Melancholy of a Street (1914), classical statues, dark arcades, and small, isolated figures are overpowered by their own shadows and by severe, oppressive architecture.
Loss of gkt during neuronal development leads to a severe CNS architecture disruption that is not dependent on the Crb pathway but probably results from the disrupted localization of other membrane proteins.
At 48 h, there was loss of alveolar architecture, severe infiltration of mononuclear cells with fat cells and severe damage to the mammary gland tissues were observed (Additional file 1: Figure S1A and Additional file 2: Figure S1B).
Although the joint of the vehicle-treated mouse is clearly flooded with inflammatory cell infiltrate and displays severe loss of architecture, the joint from the apremilast-treated mouse shows a clear joint space and normal joint architecture with articular cartilage and bone preserved.
A wide spectrum of sleep disturbances ranging from almost normal patterns to severe loss and architecture disorganization are reported in cases of DOC and some patterns correlate with diagnosis and prognosis.
We showed that, over time, A53T α-syn resulted in (1) decreasing levels of striatal TH, (2) increasing rates of DA turnover, (3) progressively more severe dystrophic axonal architecture, (4) a rise and subsequent fall in striatal DAT, (5) a loss of TH-ir cells in the SN and (6) a sustained behavioural impairment.
