A clinically most relevant factor is Panton-Valentine leukocidin (PVL) because of its association with chronic, recurrent or severe skin and soft tissue infections.
Mangled limbs with severe bone and soft tissue loss present a clinical challenge in terms of reconstructive surgery, prolonged rehabilitation, physical and psychological demands on the patient, and with no guarantee of a successful outcome.
In fractures involving severe bone and soft tissue injury, bone loss or significant deformity, the use of circular fine wire fixators is an important part of the surgical armamentarium.
These so-called community-acquired cases are often more aggressive than those in hospitals: They lead to severe skin and soft tissue infections and, when the bacteria reach the lungs, pneumonia--with fatal consequences if treatment comes too late.
In this report, we evaluated the contribution of PVL to severe skin and soft tissue infection.
Severe skin and soft tissue infections (SSTI) caused by MRSA CC398 are comparable to those caused by caMRSA with respect to surgical intervention and even admission to a hospital [22], [36].
While methicillin resistant S. aureus (MRSA) are widespread in hospitals, community-acquired MRSA CA-MRS A) is increasingly responsible for severe skin and soft tissue infections, necrotising fasciitis, and a fatal form of necrotising pneumonia, in previously healthy individuals [3] [5].
Buruli/Bairnsdale ulcer (BU) is a severe skin and soft tissue disease caused by Mycobacterium ulcerans.
These deaths were in previously healthy people with community-onset pneumonia, bacteremia, or severe skin and soft tissue infection (13 ).
This development will influence clinical practice by changing the choice of empiric antimicrobial drug therapy for severe skin and soft tissue infections.
