Sentence examples for severe and difficult from inspiring English sources

Restlessness may not be severe and difficult to characterize.

In the Western US, the wildfires that sweep through forests during the summer months are often large, severe, and difficult to contain.

Acanthamoeba keratitis can be severe and difficult to treat, leading to corneal thinning and risk of perforation, and sometimes requiring PK.

Moreover, the problem was far more stark, severe, and difficult for mediaeval Christian thinkers than for modern secular philosophers, since it was doctrinally unacceptable to solve the problem by ejecting some element of the paradox all elements of the paradox were important pieces of Christian doctrine.

It has for long been viewed as a severe and difficult to treat psychiatric condition.

Chiclero's ulcer is a rare clinical presentation and is typically severe and difficult to treat.

Both the physician and the patient are confronted with a severe, potentially life-threatening and difficult to treat chronic disease.

Patients with severe and difficult-to-treat asthma represent a small percentage of asthma patients, yet they account for much of the morbidity, mortality, and cost of disease.

This case underscores the relationship between TNF antagonists and emergence of severe and difficult-to-treat opportunistic infections.

Asthma and bronchiectasis coexist in many patients, and it has been shown that bronchiectasis can contribute to severe and difficult-to-control asthma with pulmonary complications [ 33].

In the present study, 68 % of patients were RF positive, thus representing a population of patients with potentially severe and difficult-to-treat JIA who are candidates for intensive therapy.