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"The fact that we can still borrow at lower interest rates is saving us from much more severe adjustments," Mr. Rogoff said.
Insertion of the bulky Trp residue may perturb the packing of the protein, and its accommodation may require either subtle or severe adjustments of the structure depending on the position of the affected residue.
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If that bet turned sour, it would require a severe adjustment.
"Japan's economy is deteriorating broadly, and is likely to undergo a severe adjustment phase for the time being," the bank said.
With short-term interest rates already near zero and the government reluctant to spend more to whet demand, the Bank of Japan said in its forecast that "it seems inevitable that Japan's economy will continue to experience severe adjustment".
After a sharp decrease in the trend or potential GDP, a result of the severe adjustment measures that were carried out, GDP grew in a more stable fashion in the following years.
Distribution of income and wealth became more concentrated at the top; productivity growth and profit soared; wages were flat; and finally, outsourcing, foreign direct investment and the stress of bringing labor-intensive, low-wage countries like China into the world economy caused severe adjustment pain.
And while selling to China did present some of the challenges I anticipated, it brought many others that blindsided me, requiring a severe adjustment of my cultural paradigms and a flexibility of the mind that had seldom been stretched that far!
This may not be sufficient for a population with more severe adjustment problems, and considering the criticism of other trials compromising psychological interventions by reduced dose, the dose offered in a definitive trial will need careful consideration.
Since enlargement of present library toward 6000 lines are currently underway, severe adjustment of balance between number of target genes, the sequence range, number of indices and pooling individuals will be required to screen more mutants in the near future.
Solbrig and McCormick (9 ) reported that neuropsychiatric sequelae of Lassa fever have included sleep disorders (e.g., insomnia), asthenia, multiple somatic complaints, psychosis, hallucinations, personality disorders, severe adjustment reactions, dementia, mania, and depression.
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