With satisfaction came severe personal difficulties: acting the same role over an extended period, it became impossible for him to separate Ziggy Stardust and, later, the Thin White Duke from his own character offstage.
This observation strongly supports severe functional constraint acting on the coding regions of the GluR genes, especially on the functionally important domains.
Libyan leader, Muammar Gaddafi, is described as a dangerous eccentric, suffering from severe phobias and often acting on impulse.
Also, the chorus, women as well as men, are dressed throughout in severe black lounge suits, acting in a block.
In moderate to severe persistent asthma, long acting beta agonists (LABA) like salmeterol and formoterol are added to ICS [ 1].
It also places severe limits on what advocates acting on their behalf could do.
Interview With a Ketamine Chemist.
Thus, at the organ level co-expressing an activating and deactivating mutant allele could produce a less severe phenotype than either allele acting alone.
We also conclude that an acute laser-ablation of a daughter centriole in metaphase has a more severe effect on the forces acting on kinetochore than Sas-6 depletion.
Even though these variants may not have any measurable effect, cataloguing them will help identifying rare mutations, which do cause severe phenotypes and diseases, by acting as negative controls.
