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Regulators knew that, but they had no idea of how severe a problem was being created.
But why would any agency approve another version of a painkiller with hydrocodone in it when addiction to Vicodin is already so severe a problem?
Researchers debate how severe a problem adolescent gambling is, with some arguing that "people naturally cycle in and out of problem-gambling behaviors" at different times in their lives, Dr. Potenza said.
As DNA extraction is directly carried out on all members within a sample, cell aggregation is not as severe a problem for techniques such as pyrosequencing.
It has not been demonstrated that lateral gene transfer is a greater problem (or even as severe a problem) for phylogenetic reconstruction than gene duplications, multiple gene and character losses, convergent evolution, quantum and mosaic evolution [ 129], and other forms of unequal rates and modes known to confuse the historically dominant vertical phylogenetic signal.
For instance, a few late payments on a credit card is not as severe a problem as a recent bankruptcy or foreclosure.
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Lack of transmission is a severe problem in a number of states that, like Texas, want to develop their wind resources.
High concentration of fluoride, often above 1.5 mg L−1, constitutes a severe problem over a large part of India.
In Ethiopia, soil erosion is a severe problem and a major cause of the decline of agricultural productivity.
"I think he has had a severe gambling problem for a while that went untreated," Lauro told reporters.
Lameness is a severe welfare problem and a production-limiting disease in dairy farming.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com