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For association testing with rare variants, it is customary to aggregate information across several variant sites within a gene to enrich association signals and to reduce the penalty of multiple testing.
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Allele balance in probands at identified de novo variant sites.
Seven of nine variant sites were nonsynonymous.
To do this, the various potential crack sites on several variants of a typical bridge are analyzed using a probabilistic, fracture mechanics-based model.
Codons with 2-3 sitesites and several variants in each were detected in SGT1 and SGT2; such variable codons would be expected to yield proteins with highly variable amino acids in the position.
There are several variants of PyrD and HemE at this site which include an additional 1 residue indel.
Therefore, we tested several variants for their ability to shuffle a transgene between landing sites on different chromosomes.
To overcome this issue, several variants with dramatically improved binding rates were identified using a semi-rational strategy, protein ligand binding complex modeling, site-saturation mutagenesis, and HTS for faster binding kinetics.
There are several variants of the worm.
Thus, several variants were not sensitive to the conformational differences.
Peeters-Fontaines notes several variants of this work.
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