Sentence examples for several types of alterations from inspiring English sources

Several types of alterations of specific PTP functions have been reported in cancer cells, including gene deletion, allele loss, reduced expression by promoter methylation, or inactivation by point mutation or oxidation, all leading to loss-of function [ 1, 2].

The G2SBC Database contains several types of molecular alterations associated with breast cancer.

A targeted 139 gene panel, or 'selector', for NSCLC was designed by analyzing whole-genome sequencing data for several types of somatic alterations, including sequence mutations and translocations, and was shown to detect >95% of cases.

Mutations in spliceosome components may lead to several types of deregulation, including alterations of the epigenetic control of differentiation and self-renewal; they may thus result in the same defects as TF and ER mutations.

Alterations in several types of potassium currents were detected in these neurons.

Gene promoter CpG island hypermethylation is one of the earliest somatic genome alterations during the development of several types of cancers.

There is considerable evidence to implicate genetic alterations in the rapid progression of several types of malignant tumors from the early to more advanced stages.

Our results and earlier reports suggest that AKT1 mutations might be mutually exclusive with other PI3K AKT-activating alterations, although PI3K AKT-activatingequently coexist with other alterations (such although K-Ras and PIK3CAin several types of tumutations

Alterations in this pathway have been implicated in several types of cancer, including breast, prostate, and lung cancer.

Mutations in the PTPN11 gene have been detected in low frequencies in leukemia cases; however, alterations in this gene predispose patients with Noolan syndrome to several types of leukemia (mainly juvenile myelomonocytic leukemia JMML) and other types of cancer.

Alterations of the mTOR signaling pathway are common in malignancies, including several types of sarcoma.