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Fatty acid desaturases (FAD) play an important role in plant lipid metabolism and they can be found in several subcellular compartments such as the plastids and endoplasmic reticulum.
Secondly, since proteins are located in several subcellular compartments by shuttling or transporting, we found all combinations of subcellular locations of two proteins among randomly generated PPI pairs.
Polycystin-1 (PC-1), the product of the PKD1 gene, mutated in the majority of cases of Autosomal Dominant Polycystic Kidney Disease (ADPKD), is a very large (∼520 kDa) plasma membrane receptor localized in several subcellular compartments including cell-cell/matrix junctions as well as cilia.
These findings implicate that nSMase activity could contribute to BODIPY-SM hydrolysis in several subcellular compartments.
However, the fractionation of a complex structure like the cell into several subcellular compartments is not a trivial task.
Our data demonstrated that in order to play a range of role as described above it must be required that MDH has been spread across several subcellular compartments.
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Several isoforms of APX have been found in many plant species including both monocots and dicots, and are localized to various subcellular compartments.
Using the isolation technology, several omics datasets for subcellular compartments can be generated for any given cell.
Thus, synthesis of 80S ribosomes involves several steps in different subcellular compartments, and, at first glance, there seems to be no obvious reason to express r-proteins at a defined cellular localization.
These involve differential splicing or phosphorylation at several serine sites, translocation between subcellular compartments, and/or recruitment into different activation complexes.
ROS can also be generated enzymatically in many subcellular compartments by several oxidases, peroxidases, and mono- and di-oxygenases as well as by isoforms of the cytochrome P450 superfamily.
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