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We conducted several statistical comparisons and inevitably subgroup analyses involved small numbers; thus power was limited and some significant results could have resulted by chance.
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Beforehand, several statistical differential comparisons were performed to first highlight gene expression modulation that may be unrelated to the PIP gene influence, but potentially resulting from the cell line heterogeneity itself.
Second, this type of genetic study involves several hundred statistical comparisons, raising the possibility of false positives despite the statistical methods used to control for multiple comparisons.
On the other hand, Bayesian hierarchical modelling is discussed as a powerful technique in decreasing the signal to noise ratio in GWAS and for handling the problems of multiple comparisons observed in several statistical applications, for example, analyzing GWAS data (Chen and Witte, 2007; Hung et al., 2004; Liu et al., 2005).
Also, in several instances, means are stated to be higher or lower without statistical comparisons.
All statistical comparisons were performed on the raw data, but in several figures we depict results as percent changes over baseline values to aid comparison across multiple treatment groups.
There have been several methods developed to account for the loss of specificity due to multiple statistical comparisons [ 33].
For example, several statistical tests have been used to study differential expression of genes based on the pairwise comparisons of SAGE libraries.
Several statistical and graphical criterions are used to check the accuracy of the model in comparison with previous empirical equations.
Several statistical expressions describing the power spectrum of the lithospheric magnetic field can be used for comparison to regional power spectra.
Several statistical measures and graphical representation are used to check the accuracy of the models in comparison with previous empirical equations.
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