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For example, the I2D database integrates HTP-detected PPIs with PPIs from several source databases.
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Several public source databases such as PubChem [1] offering structure as well as activity information for a number of targets have been examined for their value in extracting useful structure-activity relationships (SARs).
Nowadays, there are several large open source databases with annotated bioactivities for small molecules, with comprehensive information on biological properties of millions of chemicals.
There are several open-source databases available such as the MOAD database collected by Hu et al. [88], the GLIDA database by Okono et al. [89] or the IUPHAR database by Harmar et al. [47].
Representation of targets varies greatly across source databases, and this creates several challenges.
Relative expression of the EC-restricted genes in several normal tissues was obtained using the Source databases http://source.stanford.edu.edu
Therefore, several PPI meta-databases also exist, combining information from multiple source databases [ 15- 23].
Acknowledging the weakness of this automatic location, the authors completed their study with a further pinpointing using photographic views of the residential building from several sources (Streetview and Geoportail databases, French cadaster) for the 1258 subjects considered as living within 200 m of a line.
Records turned over by carriers might be only one of several sources for such a database.
The software Multi-Strain Mass Spectrometry Prokaryotic DataBase Builder (MSMSpdbb) can merge protein databases from several sources and be applied on any prokaryotic organism.
To characterize such isolate with many specific genetic variations we used the recently in-house designed MSMSpdbb software which merges protein databases from several sources of E. coli including type strains and other commensal and pathogenic isolates.
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