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To date, several small molecule inhibitors targeting EZH2 have been investigated in preclinical and clinical trials52.
Further, the model can be used for virtual screening of several small molecule databases.
We designed and synthesized several small molecule Magmas inhibitors (SMMI) and assayed their effects on proliferation in yeast.
There are at least four distinct allosteric sites on the polymerase to which several small molecule inhibitors bind.
Several small molecule inhibitors of CCR5 that block chemokine binding and HIV-1 entry are being evaluated as drug candidates.
As part of this program, the lab has developed and completed several small molecule screens that have revealed potential combination approaches for selectively killing cancer cells.
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Several small-molecule hosts form inclusion compounds (ICs) with polymers.
Several small-molecule hosts form clathrates or inclusion compounds (ICs) with polymers.
Recently, several small-molecule ORL1 receptor ligands were reported by pharmaceutical companies.
There are several small-molecule inhibitors of the tyrosine kinase activity of VEGF receptors in clinical trials.
This kinase led to the discovery of several small-molecule inhibitors, imatinib being the first and most successful of these.
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