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Mycobacterium tuberculosis, the causative agent for tuberculosis has employed several signalling molecules to sense the host cellular environment and act accordingly.
Epithelial clusters of non-dividing cells known as enamel knots express several signalling molecules, and thus participate in regulating the formation of both crown base and occlusal elements.
Indeed, our screen results reveal that several signalling molecules exert significant control over O-glycosylation initiation.
Several signalling molecules, some with key roles in the pathogenesis of CKD, induce stabilization of HIF-1α under normoxia.
The results revealed that these two genes were regulated by several signalling molecules including hydrogen peroxide and the phytohormone jasmonate.
Intra-cellular signalling is mediated through TNF-R1 and TNF-R2, which upon binding of TNFα will recruit several signalling molecules [ 98].
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Other potentially important transcripts figure included cytokine receptors, 2 subcomponents of complement component 1q, at least 9 interferon-inducible genes and several signalling molecule transcripts.
We propose that, as a consequence of NOX4 activity, one (or several) signalling molecule(s) is generated by stromal cells to modulate, in a paracrine manner, epithelial migration.
A Bio-Plex mouse cytokine assay (BioRad) for simultaneous quantification of the concentrations of several signaling molecules (IL-6, IL-10, G-CSF, GM-CSF, IFN-γ, CXCl1, CCL2, CCL5, and VEGF) was run according to the recommended procedure.
The B cell-specific cell surface molecule CD19 plays a role in regulating immunoglobulin (Ig) receptor signaling, and cross-linking CD19 activates several signaling molecules in mature human B cells.
This pathway may involve several signaling molecules including PKCs that are regulated by Dsg3.8, 9, 10 These findings will advance our understanding of the role of Dsg3 in tumor progression and invasion, and likely facilitate development of new therapeutic strategies for the head and neck and lung cancers.
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