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Shari Anne Brill, senior vice president and director for programming at another New York media agency, Carat, described the NBC plan as "a smart idea," likening it to steps that Fox Broadcasting has tried in the past, announcing several schedules for a season, with new shows coming on the air in September, November and January and in the spring.
Several schedules of 5-fluorouracil (FU) and irinotecan (IRI) have been shown to improve overall survival in advanced colorectal cancer (CRC).
Its prolonged half-life (40 100 h) favoured the evaluation of several schedules in a phase I clinical trial (Biondo et al, 2011; Yap et al, 2011).
In view of these promising data, seliciclib has been studied in early clinical trials in patients with advanced cancer, utilising several schedules to further evaluate its safety, tolerability and PK properties.
In our study we looked in retrospect, whether the immunohistochemical expression of TS and Topo I (which is the target of irinotecan) had any predictive significance in a large cohort of patients with colorectal cancer, who received several schedules of 5-FU-based adjuvant chemotherapy.
Furthermore, for the era of cytotoxic chemotherapy, several schedules of administration were concurrently examined in different phase I trials, detailed pharmacokinetics studies were performed, and the recommended dose and schedule was largely based on an analysis of the safety profiles, pharmacokinetics considerations, and preliminary hints of activity.
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There are still several scheduling issues to be worked out, Mr. Wolfe said.
Highland games take place around the United States and Canada all year, with several scheduled this fall.
Ms. Prejean was fired in June by pageant officials who said she missed several scheduled appearances.
[C5.] NBC announced several schedule changes in an effort to rebuild its Thursday night comedy lineup.
Those travel restrictions also placed several scheduled away games for the service academies in jeopardy.
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