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The protein encoded by orfA is similar to several replication (Rep) proteins of plasmids replicating by a rolling-circle mechanism.
Our model can, in principle, be generalized to describe chromosomal configurations in faster growing cells that have several replication forks.
Our study showed that T. cruzi inhibits HIV-1 replication at several replication stages in macrophages, a major cell target for both pathogens.
As mentioned, with the current algorithm we cannot make theoretical predictions about the chromosomal arrangements if several replication forks are moving along the DNA.
Passive DNA demethylation resulting from lack of DNMT1 maintenance activity requires indeed several replication cycles.
Clearly, the study's large sample size is an important strength, as is the availability of several replication cohorts.
Similar(37)
Several replication-competent or replication-defective nonhuman adenoviral vectors have been developed and investigated for their potential as vaccine-delivery vectors.
The aim of the general idea of data replication is placing replications at different places, while there are several replications of a specific file at different points.
In each of several replications of one male housed with three females, radioactivity was reliably observed in the uterus of all females, and in many other tissues in almost every female.
Since then, there were several replications of the finding, including both the 2000 and 2006 versions of the "Sexual Victimization of College Women" studies, which arrived at 1 in 4 female students experiencing attempted or completed sexual assault.
To date, several replication-competent recombinants based on VACV viruses have been used as vaccine vectors for many infectious diseases, demonstrating that they are able to elicit potent humoral and cell mediated immune responses, and they are able to confer lasting protection while maintaining a safe phenotype [20], [21], [22], [23].
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CEO of Professional Science Editing for Scientists @ prosciediting.com