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Genetic therapy of HCC faces severe challenges, since HCC involves genetic alterations of multiple genes in several regulatory pathways simultaneously [ 8].
Several regulatory pathways, typically involved in immune cell homeostasis, are co-opted by cancer cells to thwart the development of effective antitumor responses.
ERK protein is involved in several regulatory pathways that regulate cell proliferation and survival [ 40].
Several regulatory pathways exist to authorise medicines in the European Union (EU).
Theoretically, several regulatory pathways could influence CLDN1 protein synthesis and expression.
Mammalian cells respond to ionizing radiation through several regulatory pathways involved in the control of several cellular functions such as cell cycle arrest, DNA repair and apoptosis (1).
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We identified new key targets of lovastatin, and revealed involvement of several regulatory cellular pathways in the cytotoxic effects of lovastatin on breast cancer cell lines.
In addition, we report on several genetic regulatory pathways that have been described only in rice.
For instance, aspects of regeneration are often regulated by complex mechanisms of activation for several growth regulatory pathways in damaged tissue.
Of these, several immune regulatory pathways were identified as being differentially expressed in CMCs.
Inhibitors of HSP90 have been developed that can simultaneously modulate several intracellular regulatory pathways [ 77].
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