Sentence examples for several proinflammatory genes from inspiring English sources
Injections of Aβ42 in the cortex of rats induced severe cortical inflammation and the expression of several proinflammatory genes - including inducible nitric oxide synthase/nitric oxide synthase-2, IL-1β and IL-6 - within hours.
Due to the lower concentration of tumor necrosis factor-α in media coupled with a downregulation of several proinflammatory genes, we concluded that AA, rather than Gln, alter the inflammatory response of bovine blood PMN.
Several proinflammatory genes exhibited this expression pattern.
FOXO1 promotes inflammation by increasing expression of several proinflammatory genes.
NO triggers the transcription of several proinflammatory genes [ 28, 30], interacts with the cysteine residues of many proteins (S nitrosylation) and may alter their structure and function.
Among the transcription factors induced by Ang II, nuclear factor κB (NF-κB) plays a crucial role in regulating several proinflammatory genes, including the IL-8 gene [ 47].
Transcription factor NF-κB mainly regulated the expression of several proinflammatory gene products TNF and its superfamily members [ 34].
Cell activation by a variety of extracellular signals such as oxidative stress, cytokines, and lipopolysaccharide induces a cascade of events that leads to the degradation of IκB; activated NF-κB then translocates to the nucleus, where it binds to DNA elements in the promoters of several proinflammatory gene families [ 4].
In epithelial cells, intracellular bacteria have been observed to up-regulate several proinflammatory cytokine genes (TNFA, IL1B and IL6) and chemokine genes (IL8 and CCL20) (as referenced in [ 63] and therein).
On the other hand, the Peli1 deficiency reduced the induction of several proinflammatory cytokine genes, likely due to the role of Peli1 in mediating TRIF-dependent NF-κB activation [ 16].
Second, our specifically designed gene silencing probes clearly showed strong effects on several proliferative and proinflammatory genes, whereas the knock-down of the canonical receptor had no effect.
