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Several potential substrates have been described, most convincingly LRRK2 as being its own substrate subjected to autophosphorylation [8], [11], [15].
Furthermore, by grouping several potential substrates, role played by a protease can be discerned or new functions assigned far more confidently than when dealing with isolated substrates.
Several potential substrates of MMP-11 have been identified and include Collagen VI, Laminin Receptor, α1-Proteinase Inhibitor, and Insulin Like Growth Factor (IGF) Binding Protein 1 [ 30, 45– 45].
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However, several potential substrate-binding residues are substituted in animal KDM1B, suggesting possible changes in substrate specificity of these proteins.
Mechanisms by which mu- and delta-opioid receptors regulate motor impulsivity remain to be elucidated: there are several potential neural substrates for opioid-controlled disinhibition.
Recently, several potential mRNA substrates of Fto, including Drd3, Kcnj6, and Grin1 in the dopaminergic signaling pathway, have been identified by comparing mA-IP (immunoprecipitation -enriched mRNA peaks from the wimmunoprecipitation -enriched Fto–/– mRNAe brain.
Several compounds were tested as potential substrates for CYP75A31.
Analysis of the primary sequence of the BACE1 substrates suggests several potential sites of cleavage.
Several potential thermostable enzymes acting on lignocellulosic substrates at elevated temperatures have recently been characterized [ 13, 14].
Several metal ions have been reported as potential substrates (15).
NO receptors are potential substrates for phosphorylation by several kinases but physiological regulation through such modifications remains to be clarified (reviewed in Pyriochou & Papapetropoulos, 2005).
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