Sentence examples for several point mutations from inspiring English sources

One of these TS-clathrin mutants was a frameshift mutant [24] two were deletion mutants [23], [25] and one carried several point mutations [22], [38] but further analysis showed that glutamic acid (E1590) mutated to lysine within the trimerization region (hub) was the most important one for the TS-phenotype [36].

Sequencing these fragments revealed high homology, with several point mutations, four deletions in female and one in the male sequences.

When the functional expression of Rubisco in E. coli reached a "saturated" level, several point mutations could hardly improve its expression level further.

Several point mutations had been introduced to optimize the C-cap and were shown to indeed further increase the stability of DARPins.

The essentiality of several point mutations in ssrA was tested in H. pylori.

There are several point mutations associated with familial forms of AD.

To dissect the importance of the JunB-binding site in the 5′-flanking region of the IRE1a gene, several point mutation reporter constructs of −2065 IRE1a-luc were generated and their transactivation by JunB tested.

Alterations in Ret gene are related to several neoplasias: point mutations are identified in medullary thyroid carcinoma (MTC) and multiple endocrine neoplasias 2A and B (MEN2A and B), while translocations and chromosomal inversions cause papillary thyroid carcinoma (PTC).

In addition, although not directly located in the signaling motifs, several random point mutations in the porter TM interface region were found to reduce the transport activity of MexB (e.g., S462F in the loop connecting TMs 5 and 6, E864K, V928M, and G1002D in the N-terminal (periplasmic) regions of TMs 8, 10, and 12, respectively) (Middlemiss and Poole 2004).

Indeed, we detected several different point mutations in the resistant sublines leading to amino acid substitutions.

We found that several single point mutations exist that significantly disrupt RNA secondary structure in the five transcripts we analyzed.