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Currently it is unknown whether biological properties of rocaglamide derivatives may be explained by a common mechanism, such as inhibition of cap-dependent translation or several pathways are being engaged simultaneously or selectively.
The mechanisms whereby particles induce the formation of hROS in solution and in vivo are not fully understood, however several pathways are recognized [for a review, see [16]].
Several pathways are involved in the production of superoxide in normal cells and tissues such as xanthine oxidase, the mitochondrial electron transport system enzymes, NAD(P H oxidase, etc. [72].
Several pathways are involved in the regulation of the growth and maintenance of neovasculature, a process that can be mediated by proangiogenic factors secreted by both tumor and stromal cells (Saharinen et al., 2011).
We observed that hyper-expression of recombinant protein tends to generate a very strong response where several pathways are affected, most importantly the transporters and the cellular degradation machinery like the osmoprotectants (proP and proW), proteases (yaeL) and mRNA degradation (pnp).
This may support the hypothesis that several pathways are hijacked by CHIKV to penetrate into its target cells.
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However, several pathways were associated with selected modules.
Since several pathways were mapped to more than one dataset, these pathways could be ascertained with high confidence.
Several pathways were more highly enriched in this gene list as compared to a list of predicted targets of 9 random miRNAs (Table 1 and Table 2).
Several pathways were significantly affected in pterygium.
Several pathways were also enriched across multiple networks.
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