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Several pathway databases have recently become available, with curated information on biochemical reactions.
Therefore, with the advancement in web development technologies [16], several pathway databases have started to release integrated pathway maps that allow comprehensive viewing.
We downloaded the canonical pathways in the C2 curated gene sets, which contains 639 gene sets obtained from several pathway databases, including the KEGG (Kyoto Encyclopedia of Genes and Genomes) database [29] and the GenMAPP [30].
GSEA and ssGSEA were run against the Canonical Pathways database comprising gene sets from several pathway databases.
We collected a total of 553 human genetic pathways from several pathway databases on August 16, 2004.
Results from the methods are presented, demonstrating their applications in biological studies and comparing with a pathway web-based framework that also combines several pathway databases.
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Yu et al. [ 15] have combined several pathway database to create another integrated pathway database (hiPathDB) with 1661 human pathways.
In order to understand what these PPIs may better correspond to, we collect pair-wise protein/gene relationships (mainly the ECrel and PPrel datasets, see Table 7) from several major pathway databases, and compare them with the various PPI datasets considered earlier in this paper.
Accordingly, several signaling pathway databases have been created manually by collecting relevant data from the literature [20].
The composition of a pathway can be artificially defined or acquired from several public pathway databases.
MSigDB integrates several different pathway databases, we use KEGG, Biocarta and Reactome.
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