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Abnormalities of PPAR gamma are observed in several pathological states such as cancers, diabetes, obesity, and atherosclerosis.
Deregulation of PRMT activity has been linked to several pathological states such as cancer and cardiovascular disorders.
Several pathological states such as starvation [53], parasite attack [54], nutritional imbalances [55], and hemolytic anemias [53], can enhance macrophage aggregate appearance.
The basal ganglia (BG) are critical for the coordination of several motor, cognitive, and emotional functions and become dysfunctional in several pathological states ranging from Parkinson's disease to Schizophrenia.
Given that TNFα is now invariably being associated with several diseases, our results provide information towards identification of the underlying genes and transcription factors that determine among other significant liver phenotypes, hepatic steatosis and fatty liver that are critically associated with several pathological states.
It has been proposed that antioxidant changes reflect an altered redox balance in several pathological states.
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S6K is involved in several signaling pathways [ 76, 77] that contribute to various pathological states, including aging-related pathology [ 78, 79] and extending the life span of mammalian cells [ 79].
These could possibly determine TNFα mediated alterations mainly the phenotypes of hepatic steatosis and fatty liver associated with several hepatic pathological states.
Although earlier studies [24], [25] have shown some specific effects of TNFα on HepG2 cells, our results demonstrate a wholesome analysis of TNFα effect on HepG2 cells that correlates the altered transcriptome profile with identification of conserved transcription factor binding sites that could determine several hepatic pathological states.
A deregulation of the hypothalamic NPY system has been proposed to be related to several pathological and pathophysiological states including cancer cachexia [ 99], hyperinsulinemia and hypercorticism [ 100], obesity and metabolic syndrome [ 101], and anorexia [ 102].
Biomarkers levels, in fact, may be modified by several tumor-independent physiological or pathological states, like menstrual cycle, pregnancy, metabolism, inflammation, and liver and/or renal function [ 5].
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