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There are reports based on functional genomics studies of several organisms, which indicate that only 15 - 20% of the genes are essential to the organism under a given condition [ 12].
Orphan NikK and/or NikL orthologs were also observed in several organisms which lack NikMQO but contain Ni-dependent proteins, or even lack Ni utilization (see Additional files 1, 10 and 11].
However, it must be noted that there was a tendency for several organisms which are naturally more resistant to certain antibiotics (such as Enterobacter spp. or Pseudomonas aeruginosa) to be more frequent in HCA.
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Furthermore, the project was able to explore the putative association of several organisms for which a causal relationship with encephalitis remains tenuous, such as rotavirus (24 ), human metapneumovirus (25 ), and Mycoplasma pneumoniae (13 ).
High diversity of the major histocompatibility complex locus has been found in several organisms in which the diversity of neutral evolving loci was low, e.g., in voles (Oliver & Piertney 2012) and foxes (Aguilar et al. 2004).
Flaviviridae-host genome coevolution is mediated by a rich and complex sum of factors caused by several coadaptational events in both organisms which, acting on several levels, such as the dinucleotide and codon structures, convergently shaped nucleotide motif usage in such contrasting groups.
In recent years there has been increasing reports on predicted highly expressed genes in several micro-organisms which provide a wealth of information about gene expression.
Temperature and salinity are important factors that affect several physiological processes in aquatic organisms, which could be produced by variation of certain hormones.
Several of them exhibited significant activities against Gram-positive organisms, which were more potent than those of gemifloxacin, Linezolid, and vancomycin.
However, there are several mechanisms to repair the damaged DNA in the living organisms, which are responsible to maintain the stability of genetic material.
In the next several decades, dubbed the 'Golden Era' of antibiotic discovery, twenty new classes were discovered, largely from soil-dwelling organisms – which have produced antibiotics as a natural product for millennia.
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