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Several organ dysfunction scoring systems have been developed to describe and quantify organ dysfunction/failure in ICU patients [ 6- 8].
In this additional investigation, the 95% CIs of the differences in the incidence rates of several organ dysfunction lay on either side below zero, indicating a statistically significant difference between both groups.
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On admission, most patients had several organ dysfunctions with a median organ failure score of 3 (range 2 to 4).
The PATH registry captures data on several organ dysfunctions associated with mortality in critically ill septic patients and typically incorporated into acuity models: respiratory (present in all patients included in this analysis), renal, and hepatic.
By univariate analysis several organ dysfunctions (respiratory, cardiovascular, renal and hematologic) were associated with death, but age, hepatic failure, inappropriate antimicrobial therapy, imipenem resistance and polymicrobial infection were not.
Several mechanisms may explain the AVP-related less severe organ dysfunction and tissue injury.
Several studies have directly compared the various organ dysfunction scoring systems.
Cardiovascular dysfunction was the most severe organ dysfunction, followed by pulmonary, renal and neurologic dysfunction.
Several multiple organ dysfunction scoring systems have been developed, but the SOFA score and the Multiple Organ Dysfunction Score [ 7] are the most commonly applied.
Although several multiple organ dysfunction scoring systems [ 3] have been described, the Sequential Organ Failure Assessment (SOFA; Table 1) score [ 4] and the Multiple Organ Dysfunction (MOD; Table 2) score [ 5] are most commonly applied.
Several specific organ dysfunctions had correlations with cytokine production in different times.
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