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Transcriptional activation, like that mediated by STATs, is one of several nuclear processes regulated by alterations to the chromatin fiber.
WRN is a nuclear protein that has been implicated in several nuclear processes ranging from DNA repair, transcription, recombination and telomere metabolism [ 18].
Williams syndrome transcription factor (WSTF) is a multifaceted protein that is involved in several nuclear processes, including replication, transcription, and the DNA damage response.
This complex includes: Mre11, Rad50, and Xrs2/Nbs1, and plays a vital role in several nuclear processes including DNA double-strand break repair, telomere length maintenance, cell cycle checkpoint control, and meiotic recombination in eukaryotes [ 78, 79].
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The tripartite cohesin ring is particularly suited to determine chromosome architecture, for it is large and dynamic, may acquire different forms, and is involved in several distinct nuclear processes.
Not surprisingly, actin was also detected in the nucleus, which has been previously implicated in several different nuclear processes, such as transcription and chromatin remodeling [14].
The SET-CAN fusion protein dysregulates several potentially oncogenic nuclear processes, including aberrant retention of proteins targeted for export, stimulation of the wnt signaling pathway, and transcriptional activation of HOXA target genes [ 28– 30].
Furthermore, coexpressed genes presented here are not limited to nuclear processes given that several cytoskeletal proteins are identified in the screening, implicating p68 and p72 in these processes (although probably indirectly as p68 and p72 are predominantly nuclear, perhaps acting via transcription or splicing).
Several nuclear factors are implicated in the process including FUS/TLS (fused in sarcoma/translocated in liposarcoma) which facilitate Drosha recruitment to certain specific miRNAs (e.g., miR-125b) in a neuroblastoma cell line (Morlando et al., 2012).
Phosphatidylinositol 3-phosphate is involved in regulation of several key cellular processes, mainly endocytosis, signaling, nuclear processes, cytoskeletal remodelling, cell survival, membrane trafficking, phagosome maturation and autophagy.
Nuclei of higher eukaryotes are highly organized and can be divided into several nuclear compartments containing distinct sets of proteins that are essential for particular nuclear processes (reviewed in Spector 2001).
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