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This modular logic of biosynthesis has been exploited with reasonable success to produce several novel compounds by genetic manipulation.
Several novel compounds have been identified that inhibit the replication of hepatitis C virus in a replicon assay with EC50 values as low as 0.6 μM.
We here describe the preparations of a range (1 16 below) of examples of resveralogues including several novel compounds (2, 4, 6, 8, 15 and 16), in good yield and purity, with minimal waste and manipulative steps.
Several novel compounds are under investigation.
Several novel compounds eliciting antiviral mutagenesis in cell culture were recently identified (Levi et al., 2010; Mullins et al., 2011; Baranovich et al., 2013; Dapp et al., 2014).
Sequencing of large numbers of fungal genomes will allow us to understand the diversity of genes encoding enzymes, and pathways that produces several novel compounds [ 24].
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In summary, several novel macrocyclic compounds are reported that appear to block the Shh pathway by inhibiting the membrane protein Smo.
Several structurally novel compounds were designed based on the theoretical models and finally synthesized.
Several of such novel compounds display potent JNK inhibitory profiles both in vitro and in cell.
Several of the novel compounds showed GI50 values at a nanomolar level on the majority of the tested cell lines.
Several of the novel compounds – in particular the ethylketone-derived HPPI, NHAPI and acetyl-substituted A2,4DHAPI – merit deeper investigation as promising potent and selective anticancer agents.
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