There are several notable experimental differences between the studies which are likely to impact on the final results; a primary one being that we, in contrast to Fan et al., used full-length Sup35 rather than the NM fragment.
There are several notable policy differences among these models, including physician payment schemes, composition and degree of multi-disciplinarity within the team, and priorities, such as populations served and according to which principles.
These studies together suggest that although the genomic organization of all paralogs is relatively well conserved, several notable structural differences that influence either coding sequences and/or transcript processing have indeed contributed to paralog divergence across taxa.
Although the contacts of Mot1NTD and NC2 within the complex are mainly TBP- and/or DNA-mediated, which is consistent with the lack of a stable interaction between Mot1 and NC2 in the absence of DNA in vitro (data not shown), we observed several notable conformational differences.
In addition to the absence of the timeline cyclical dimension and the combined consequence and control negative dimension, several other notable differences can be found.
