Sentence examples for several negative regulators from inspiring English sources
It is known that the regulation of this pathway is highly complex, with several negative regulators being up-regulated in a cell with active Wnt signalling.
Specifically, we note the up-regulation of the NFκB inhibitors NFKBIA and NFKBIZ, and the up-regulation of several negative regulators of the innate sensing receptor retinoic acid-inducible gene 1 (RIG-I -like RIG-I -likeRIG-I -likeuding USP18, ISG15, DHX58 and tumoreceptorss factoRLRspha-includingndUSP18proteISG15(TNFAIP3).
In particular, many studies have demonstrated that the p38-MAPK pathway antagonises cell proliferation and regulates proapoptotic signalling; accordingly, several negative regulators of p38-MAPK have been found to be overexpressed in human tumours and cancer cell lines.
Several negative regulators including Wee1, an inhibitor of the cell cycle-regulatory kinases CDK2 and CDC2, as well as CDC27, a component of the anaphase-promoting complex, are cleaved by caspases.
Several negative regulators have been shown to be expressed in the mature enterocyte [13], [14].
Several negative regulators of insulin signaling are known and are the subject of drug discovery efforts.
Moreover, proteomic analysis revealed the stronger downregulation of several negative defence regulators in infected GC plants compared to infected wild-type plants, which may compensate for the weaker defence response in GC plants and yield a normal resistance phenotype.
Meanwhile, several negative master regulators of rice disease resistance, including NRR, OsWRKY62 and Os-11N3, were up-regulated in jmj704, suggesting that JMJ704 positively regulates rice BB resistance via epigenetically suppressing the transcription of negative regulators during the pathogen infection.
The screen identified several known negative regulators of apoptosis as negative regulators of TRAIL-induced caspase-3/7 activation, including BCL2L1 (BCL-XL), BCL2L2 (BCL-w), BIRC2 (c-IAP1), and BIRC3 (c-IAP2) [ 24, 25].
Notably, there are several important negative regulators of Fas-induced apoptosis including B-cell lymphoma-2 (BCL2), FLICE-like inhibitory protein (FLIP), and baculoviral IAP repeat-containing protein 2 (Iall), all three of which demonstrate NF-kB-dependent transcription [ 36, 37].
The identification of several established negative regulators of apoptosis as negative regulators of TRAIL-induced caspase-3/7 activation, including BCL2L1 (BCL-XL), BCL2L2 (BCL-w), BIRC2 (c-IAP1), and BIRC3 (c-IAP2), lends further support to the validity of the screen results.
