Thirdly, that the effects of the several mutations in the set are roughly independent and therefore strong trade-off and sign-epistasis effects do not occur.
In a replication study investigating almost 400 ASD patients from Italy, Finland, and the UK, several mutations in the ASMT gene were identified, including the previously reported splice site mutation and a novel stop-mutation (R319X) [ 19].
Several mutations in the two parts of the central "crest" of the arrestin molecule, middle-loop and C-loop, enhanced or reduced arrestin-3 interactions with several GPCRs in receptor subtype and functional state-specific manner.
Past genetic screens in zebrafish identified numerous defects of ciliogenesis, including several mutations in the components of the intraflagellar transport machinery.
These results suggested broad combined effects of several mutations on the phenotype of the strains.
Furthermore, this study also describes the influence of several mutations on the enzymatic activity of LinB and helps in understanding the structure-function relationship.
Surprisingly, we found a very strong correlation as confirmed by several mutations in the sequence predicted to influence the stability of the RNA.
Several mutations altering the binding site at the ribosome have been found [ 3, 21].
However, several mutations in the kinase domain of the BCR-ABL Oncogene occur even before exposure to imatinib [44].
This is in apparent contrast with a recent study (29) who found that several mutations including the R374Q studied caused the helicase to be completely monomeric.
