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The structures of proteins and other biological molecules are determined by the delicate balance between several molecular interactions [1 3].
Nevertheless, taking into account the complexity and the several molecular interactions that constitute the cascade of events associated with resistance and endurance exercise, conclusions should be drawn with caution.
Translation initiation, the rate-limiting step of protein expression, is determined by several molecular interactions, such as the complementarity of the RBS sequence to 16S rRNA, the spacing between RBS and the start codon, and the presence of mRNA secondary structures (Salis et al. 2009).
The Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway [ 15] is a description of several molecular interactions and how they are organized in a biological pathway.
The molecular analysis of this amino acid substitution showed this mutation can substantially destabilize the functional capability of RNase L because this substitution eliminates several molecular interactions of the wild type Arginine residue.
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MImerge and MIscore were used to calculate the score distribution across several molecular interaction databases (Table 3).
The human PPI network was constructed by integrating human PPIs from several molecular interaction databases, both public (BIND, BioGRID, HPRD, MINT, Reactome, DIP, and IntAct) and commercial (Ingenuity, Proteome, MetaBase, and NetPro).
Collectively, these data support the view that (1) one or several distinct molecular interactions with the host cell surface specifically trigger the RON complex secretion, and (2) a one-shot secretion is used for junction assembly into the host cell PM.
The mechanism of action of metformin involves several pathways and molecular interactions.
We were able to uncover and analyze several networks of molecular interactions responsible for the change of resistance levels to six antiviral drugs.
Since signalling pathways involve several types of molecular interactions including protein-protein interactions, we postulated that investigating their organization in the context of the global protein-protein interaction network could provide a new integrated view of signalling mechanisms.
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