Sentence examples for several molecular abnormalities from inspiring English sources
Colorectal cancer develops from benign precursors, the adenomatous polyps; there is extensive evidence that polyps transform into cancer in a stepwise manner, and that several molecular abnormalities (mutations of oncogenes, inactivation of tumour suppressor genes and microsatellite instability) accompany and, somehow, determine colorectal tumourigenesis.
Within the CN group, several molecular abnormalities have been associated with prognosis.
Recently several molecular abnormalities were reported to associate with sensitivity or resistance to EGFR inhibitors, including somatic mutations in the EGFR tyrosine kinase domain, EGFR gene amplification, KRAS mutation, and MET amplification [14], [15], [16], [17].
If one or several molecular abnormalities were identified, then patients were randomised.
PP2Ac regulates CREB, Elf-1, and SP1, and could thus contribute to several molecular abnormalities described in SLE T cells.
Several molecular abnormalities have been described for OSCC, particularly mutation of the p53 tumour suppressor gene (Forastiere et al, 2001; Le and Giaccia, 2003), but the molecular biology of OSCC of different degrees of differentiation is not well understood.
Genetic analysis revealed various molecular abnormalities (Table 1 and Fig. 2).
In fact, for several actionable molecular abnormalities, including ALK rearrangements, the median age of onset may be several years younger than for the general lung cancer population (Weickhardt and Camidge, 2011).
The complex process that drives the development of leukemia could rise from several clonal molecular abnormalities, including copy number gains and losses in the genome leading to activation of proto-oncogenes and silencing (or deletion) of tumor suppressor genes, respectively [3], [4].
Multiple histologic subtypes were recognized and several molecular and genetic abnormalities were variably present.
In case of several alterations, the prioritization of the molecular abnormalities is discussed by the MBB based on the following criteria: (1) In case of expression of both AR and ER/PR in a same patient, the hormone receptor with the highest expression level is taken into account.
