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A remote control strapped to one wrist offers several modes of action: "stand", "sit", "walk", and "ascend" and "descend" for staircases.
However, several modes of action as well as multiple sites of action have been proposed.[3].
Similarly, detrimental effects on embryonic development have been reported for different types of nanoparticles and several modes of action were proposed.
Several modes of action have been suggested for the anti-apoptotic activity of Mcl-1.
The EDCs act through several modes of action to cause effects on sensitive tissues.
Several modes of action are implicated [ 45], especially the synthesis of phytohormones such as indole-3-acetic acid [ 3, 54].
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At this level, several mode of actions have been suggested (see Fig. 1).
Therefore in this work, a killing assay was performed, evaluating the impact of several cell inactivation techniques with various modes of action on EMA/PMA-qPCR results.
Hence, there is a need to develop a therapeutic approach that would (i) increase the sensitivity of the microorganism to already established methods (e.g., antibiotic therapies) by violating the structure of the biofilm or disturbing the communication between a population of microorganisms in the biofilm or (ii) combine several modes of microbicidal action to achieve a synergistic effect.
Although several modes of VPA action have been proposed [e.g., histone deacetylase (HDAC) and protein kinase (PKC) inhibition, extracellular signal-regulated kinase (ERK) and activator protein-1 (AP-1) activation, and effects on the actin cytoskeleton] (Blaheta and Cinatl 2002; Gurvich and Klein 2002; and Walmod et al. 1999), the mechanism of VPA teratogenicity remains poorly understood.
Several other modes of action were reported and next to these primary responses, it is likely that higher concentrations of the α-chloroacetamide lead to additional secondary physiological reactions [5 9].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com