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Of particular interest is the significant (p<0.05) but modest elevation of AEA in subjects with the FAAH 385 mutant A alleles (Figure 1), since AEA activates the CB1 receptor and has the potential to stimulate appetite and feeding behavior as well as modulate several metabolic functions including fatty acid metabolism and contributes to diet-induced obesity [12], [16].
This initial adaptation was followed by a transcriptional increase in several metabolic functions.
However, several metabolic functions that are missing in N. equitans are predicted for Nst1.
Although animal research indicates that BPA can alter several metabolic functions, interpretation of human data has been more controversial.
ApoE has three polymorphic variants (ApoE2, ApoE3, and ApoE4) and is involved in several metabolic functions, including lipid transport [ 8, 9].
Several metabolic functions and processes are constantly and concurrently maintained in the liver, which is a complex organ performing a plethora of vital functions [ 15].
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Meta-analysis of several clinical studies revealed a connection between E2 and control of several key metabolic functions including abdominal obesity, insulin sensitivity, lipid transport, blood pressure, and inflammatory or prothrombotic states [ 25].
Vitamin D has several important metabolic functions, including regulation of calcium movement in gastrointestinal mucosa, renal tubules, and the skeleton [1].
Each module consists of enzymes involved in one or several particular metabolic functions.
Vitamin B1 (thiamine pyrophosphate) is involved in several microbial metabolic functions [ 70].
Thiamine pyrophosphate (Vitamin B1) is involved in several microbial metabolic functions [ 63].
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