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A group of studies showed several mechanisms in which FoxO1 can antagonize Pdx-1.
In a 2006 review, (Ladurner, 2006) described several mechanisms in which metabolites can tune gene expression; they include riboswitches, direct interactions with transcription factors, regulation of cofactors, chromatin remodeling, chromatin modification and hormone signaling.
There are several mechanisms in which aspirin can manipulate the processes involved in both sepsis and ARDS (Fig. 1): 1) inhibition of COX [ 43]; 2) inhibition of nuclear factor kappa B (NFκB) [ 44]; 3) production of nitric oxide (NO) [ 45]; and 4) lipoxin production [ 46].
Mst1/2 can be activated by cellular stressors and the activation of Mst1/2 might enforce a feedback stimulation system to regulate oxidant levels through several mechanisms, in which regulation of cellular redox state might represent a tumor suppressor function of Mst1/2.
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Several possible mechanisms in which oxygen may influence phosphorylcholine metabolism are suggested.
A balanced output of the vertebrate immune response is dependent on several regulatory mechanisms, in which microRNAs (miRNAs) have recently emerged as new players with critical importance [ 1].
There are several proposed mechanisms in which laparoscopic cystectomy may worsen ovarian reserve including accidental removal of healthy ovarian cortex, thermal damage from coagulation of bleeding vessels, and surgical-related local inflammation [ 44].
These efforts have led to the broad consensus that dementia is a multi-factorial disorder caused by several interrelated mechanisms in which the interaction of genetic and environmental factors plays the major role (Table 1).
And the FDA already has several mechanisms in place to speed promising new therapies to market.
There are several mechanisms by which variants in non-coding regions of the mRNA transcripts could affect gene function.
These intriguing results indicate several mechanisms by which mutations in checkpoint genes could cooperate with BRCA2 mutations to promote aggressive cell growth.
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