We have found that telomerase inhibition per se does not alter the sensitivity of several malignant cell lines to any of the drugs tested.
PPARγ agonists have been shown to induce apoptosis in several malignant cell lines (2, 3) and to inhibit the invasive activity of colon and breast cancers cells (4– 7).
CD47 blocking antibodies have been shown to directly induce apoptosis and to influence tumor proliferation in several malignant cell lines 22, 38.
Exogenous Cer-related autophagy was shown to trigger autophagy-associated cell death, which occurs in several malignant cell types, including colon cancer, breast cancer, cervical cancer, nasopharyngeal cancer, and glioma cells.
In addition, inhibition of TIMP-1 expression occurs in several malignant cell lines in response to TGF β, all- trans-retinoic acid, female sex hormones, and dexamethasone (Campbell et al, 1991; Wright et al, 1991).
In second place, CSF cytology showed several malignant aggregated cells in the sample.
To evaluate the utility of both CD19 and CD21 as targets for antibody-MCC-DM1 conjugates, we examined the internalization of antibodies to these antigens by immunofluorescence in several malignant B-cell lines, as well as primary B-cells and correlated the uptake with sensitivity to the respective conjugates.
Indeed, defects in key components of IFN-α induced signal transduction pathways have been noted in several malignant melanoma cell lines.
Moreover, in several human malignant cell types, including lymphoma, melanoma, fibrosarcoma, and squamous cell carcinoma, T-oligos induce differentiation, apoptosis and/or senescence [ 9, 13, 17], and strikingly reduce tumor burden in a mouse xenograft model of human melanoma [ 13].
