Recent studies suggested that resistance to apoptosis with the Fas blockade might play an important role in tumorigenesis and tumour progression in several malignancies, including colorectal cancer (O'Connel et al, 1996) and malignant glioma (Roth et al, 2001).
Overexpression of EGFR is found in several malignancies including lung cancers.
Amplification of EZH2 has been reported in several malignancies, including prostate, breast, and lymphoma.
Vascular endothelial growth factor (VEGF) has emerged as a therapeutic target in several malignancies, including cervical cancer.
Dysregulation of MAL (myelin and lymphocyte protein) has been implicated in several malignancies including esophageal, ovarian, and cervical cancers.
Several malignancies, including breast and colorectal carcinoma, metastasise to the lungs by the way of the pulmonary arteries.
Interfering with iASPP function is therefore another mechanism that can sensitize KSHV-positive PEL cells to cell death.KSHV is associated with several malignancies, including primary effusion lymphoma (PEL).
However, EBV is also associated with several malignancies including Burkitt's lymphoma (BL), Hodgkin's disease and nasopharyngeal carcinoma [1].
Gain-of-function mutations in PIK3CA have recently been found in several malignancies, including breast cancer [1], [3], [4].
PDK1 is a key regulator of the AGC protein kinase family, which includes the proto-oncogene AKT/PKB implicated in several malignancies, including breast cancer.
Recent developments have permitted the development of gene chips containing a set of disease specific genes for either the diagnosis or predicting prognosis of several malignancies including breast and esophageal cancers [15] [18].
