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Several malignancies have been shown to express increased levels of AGR2 compared to non-malignant tissue.
If this applies to humans, it may improve staging of several malignancies.
Neutrophil-to-lymphocyte ratio (NLR), if elevated, is associated with worse outcomes in several malignancies.
Overexpression of EGFR is found in several malignancies including lung cancers.
Amplification of EZH2 has been reported in several malignancies, including prostate, breast, and lymphoma.
Intensification of cytotoxic chemotherapy enhances the outcome of several malignancies but is limited by haematotoxicity.
Several malignancies, including breast and colorectal carcinoma, metastasise to the lungs by the way of the pulmonary arteries.
The most common marker of oxidative DNA damage is 8-hydroxydeoxyguanosine (8-OHdG), which is linked with several malignancies.
Aberrations in fibroblast growth factor receptor (FGFR) signaling are instrumental to the pathophysiology of several malignancies and disorders.
Vascular endothelial growth factor (VEGF) has emerged as a therapeutic target in several malignancies, including cervical cancer.
Moreover, in several malignancies, CSCs represent a rare sub-population; therefore, whole tumor profiling might mask CSC gene expression patterns.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com