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The initiation step is thought to be the major regulatory point for most genes in vivo, despite that promoter-proximal stalled RNA polymerase II (RNAPII) has been detected at several loci including hsp70 [1], HIVLTR [2], c-myc [3], and c-fos [4].
However, several loci, including 15q24, 17q12 and 8p23, showed suggestive signals of SNP-allele correlation.
Although several loci, including the pericentromeric region of chromosome 16, have been linked to paroxysmal kinesigenic dyskinesias, the causative gene has not yet been identified.
Therefore a locus that aligned to several loci, including itself, was likely a repeat sequence and was excluded from the database.
In addition, GATA2 transcription is regulated by several loci including CEBPA, HOXA9, ETS1, BMP4, NOTCH1, SPI1 and EVI1 and by cytokines IL1 and TNFα (Vicente et al, 2012).
Human genetic lipodystrophy has been linked to several loci, including Berardinelli-Seip congenital lipodystrophy 2 (BSCL2) (Magre et al. 2001) and caveolin-1 (CAV1) (Kim et al. 2008).
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These results imply that although C5 plays a crucial role in response to C. albicans infection, several additional loci, including the locus on chromosome 11, can modulate response to infection in inbred strains.
Cre- loxP recombination efficiency in Stella-Cre mice was investigated at several genomic loci including Rosa26, Jak2, and Npm1.
Since then, increased instability of long microsatellites have been confirmed for several microsatellite loci, including HrU10 [ 30].
On the other hand, several T2D loci, including KCNQ1, were first discovered in East Asians and subsequently replicated in European populations.
Local haplotypes are well known for the major histocompatibility complex (MHC) and several other loci, including the ApoE4 haplotype of the ApoE locus.
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